Human Gene USP19 (uc011bch.2) (2024)

Human Gene USP19 (uc011bch.2)

Description: hom*o sapiens ubiquitin specific peptidase 19 (USP19), transcript variant 1, mRNA.
RefSeq Summary (NM_001199160): Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This protein is a ubiquitin protein ligase and plays a role in muscle wasting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017].
Transcript (Including UTRs)
Position:hg19 chr3:49,146,106-49,158,371Size:12,266Total Exon Count:27Strand:-
Coding Region
Position:hg19 chr3:49,146,391-49,156,578Size:10,188Coding Exon Count:26

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC:2013-06-14

Sequence and Links to Tools and Databases

Genomic Sequence (chr3:49,146,106-49,158,371)			mRNA (may differ from genome)		Protein (1419 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
H-INV	HGNC	Lynx	MGI	OMIM	PubMed
UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: E9PEG8_HUMAN DESCRIPTION: RecName: Full=Ubiquitin carboxyl-terminal hydrolase; EC=3.4.19.12; CATALYTIC ACTIVITY: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). SIMILARITY: Belongs to the peptidase C19 family. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

Primer design for this transcript


	Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA. Click here to load the transcript sequence and exon structure into Primer3Plus Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence. Click here to open Exonprimer with this transcript To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


	The following chemicals interact with this gene D000082Acetaminophen D0150842,4-Dichlorophenoxyacetic Acid C0164032,4-dinitrotoluene C0235142,6-dinitrotoluene C547126AZM551248 D016604Aflatoxin B1 D019256Cadmium Chloride D002994Clofibrate D010695Phlorhizin D013749Tetrachlorodibenzodioxin more ... click here to view the complete list


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	Highest median expression: 21.20 RPKM in Testis Total median expression: 739.72 RPKM View in GTEx track of Genome BrowserView at GTEx portalView GTEx Body Map


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See Also

Human Gene NPVF (uc003sxo.3)

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-151.20	319	-0.474	Picture	PostScript	Text
3' UTR	-111.10	285	-0.390	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR007052 - CS-like_domain
IPR017447 - CS_domain
IPR015054 - DUF1872
IPR008978 - HSP20-like_chaperone
IPR018200 - Pept_C19ubi-hydrolase_C_CS
IPR001394 - Peptidase_C19
IPR002893 - Znf_MYND

Pfam Domains:
PF00443 - Ubiquitin carboxyl-terminal hydrolase
PF01753 - MYND finger
PF04969 - CS domain
PF13423 - Ubiquitin carboxyl-terminal hydrolase
PF16602 - Linker region of USP19 deubiquitinase

SCOP Domains:
49764 - HSP20-like chaperones
54001 - Cysteine proteinases

ModBase Predicted Comparative 3D Structure on E9PEG8


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details
Gene Sorter

Descriptions from all associated GenBank mRNAs


	LF208631 - JP 2014500723-A/16134: Polycomb-Associated Non-Coding RNAs. BC106029 - homo sapiens ubiquitin specific peptidase 19, mRNA (cDNA clone IMAGE:6151634), partial cds. BC142660 - homo sapiens ubiquitin specific peptidase 19, mRNA (cDNA clone IMAGE:40148084), partial cds. BC014934 - homo sapiens ubiquitin specific peptidase 19, mRNA (cDNA clone IMAGE:3920431). BC082241 - homo sapiens ubiquitin specific peptidase 19, mRNA (cDNA clone IMAGE:4841019), partial cds. BC142727 - homo sapiens ubiquitin specific peptidase 19, mRNA (cDNA clone IMAGE:40148933), partial cds. AK300425 - homo sapiens cDNA FLJ61404 complete cds, highly similar to Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.1.2.15). BC065909 - homo sapiens ubiquitin specific peptidase 19, mRNA (cDNA clone IMAGE:4859467), partial cds. BC146752 - homo sapiens ubiquitin specific peptidase 19, mRNA (cDNA clone MGC:166816 IMAGE:9007186), complete cds. AB020698 - homo sapiens KIAA0891 mRNA for KIAA0891 protein. AK294756 - homo sapiens cDNA FLJ54450 complete cds, highly similar to Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.1.2.15). BC128088 - homo sapiens ubiquitin specific peptidase 19, mRNA (cDNA clone IMAGE:40108548), with apparent retained intron. AB384036 - Synthetic construct DNA, clone: pF1KSDA0891, homo sapiens USP19 gene for ubiquitin carboxyl-terminal hydrolase 19, complete cds, without stop codon, in Flexi system. MA444208 - JP 2018138019-A/16134: Polycomb-Associated Non-Coding RNAs. BC048269 - homo sapiens ubiquitin specific peptidase 19, mRNA (cDNA clone IMAGE:4478169), partial cds. EF036501 - homo sapiens USP19 protein mRNA, partial cds. LF378579 - JP 2014500723-A/186082: Polycomb-Associated Non-Coding RNAs. JD428795 - Sequence 409819 from Patent EP1572962. JD423762 - Sequence 404786 from Patent EP1572962. JD272625 - Sequence 253649 from Patent EP1572962. JD543901 - Sequence 524925 from Patent EP1572962. JD146330 - Sequence 127354 from Patent EP1572962. JD220811 - Sequence 201835 from Patent EP1572962. JD467861 - Sequence 448885 from Patent EP1572962. JD459465 - Sequence 440489 from Patent EP1572962. JD476479 - Sequence 457503 from Patent EP1572962. JD151841 - Sequence 132865 from Patent EP1572962. LF378578 - JP 2014500723-A/186081: Polycomb-Associated Non-Coding RNAs. LF378577 - JP 2014500723-A/186080: Polycomb-Associated Non-Coding RNAs. LF378576 - JP 2014500723-A/186079: Polycomb-Associated Non-Coding RNAs. MA614156 - JP 2018138019-A/186082: Polycomb-Associated Non-Coding RNAs. MA614155 - JP 2018138019-A/186081: Polycomb-Associated Non-Coding RNAs. MA614154 - JP 2018138019-A/186080: Polycomb-Associated Non-Coding RNAs. MA614153 - JP 2018138019-A/186079: Polycomb-Associated Non-Coding RNAs. LF378575 - JP 2014500723-A/186078: Polycomb-Associated Non-Coding RNAs. AK296447 - hom*o sapiens cDNA FLJ54466 complete cds, moderately similar to Rattus norvegicus ubiquitin specific protease 19 (Usp19), mRNA. LF378574 - JP 2014500723-A/186077: Polycomb-Associated Non-Coding RNAs. LF378573 - JP 2014500723-A/186076: Polycomb-Associated Non-Coding RNAs. LF378572 - JP 2014500723-A/186075: Polycomb-Associated Non-Coding RNAs. LF378571 - JP 2014500723-A/186074: Polycomb-Associated Non-Coding RNAs. LF378570 - JP 2014500723-A/186073: Polycomb-Associated Non-Coding RNAs. JD467568 - Sequence 448592 from Patent EP1572962. JD479864 - Sequence 460888 from Patent EP1572962. JD436430 - Sequence 417454 from Patent EP1572962. JD359967 - Sequence 340991 from Patent EP1572962. MA614152 - JP 2018138019-A/186078: Polycomb-Associated Non-Coding RNAs. MA614151 - JP 2018138019-A/186077: Polycomb-Associated Non-Coding RNAs. MA614150 - JP 2018138019-A/186076: Polycomb-Associated Non-Coding RNAs. MA614149 - JP 2018138019-A/186075: Polycomb-Associated Non-Coding RNAs. MA614148 - JP 2018138019-A/186074: Polycomb-Associated Non-Coding RNAs. MA614147 - JP 2018138019-A/186073: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: E9PEG8, E9PEG8_HUMAN, NM_001199160, NP_001186089 UCSC ID: uc011bch.2 RefSeq Accession: NM_001199160 Protein: E9PEG8CCDS: CCDS56254.1

Gene Model Information

category:	coding	nonsense-mediated-decay:	no	RNA accession:	NM_001199160.1
exon count:	27	CDS single in 3' UTR:	no	RNA size:	4878
ORF size:	4260	CDS single in intron:	no	Alignment % ID:	100.00
txCdsPredict score:	7545.00	frame shift in genome:	no	% Coverage:	99.71
has start codon:	yes	stop codon in genome:	no	# of Alignments:	1
has end codon:	yes	retained intron:	no	# AT/AC introns	0
selenocysteine:	no	end bleed into intron:	0	# strange splices:	0

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Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.