Human Gene NPVF (uc003sxo.3) (2024)

Human Gene NPVF (uc003sxo.3)

Description: hom*o sapiens neuropeptide VF precursor (NPVF), mRNA.
Transcript (Including UTRs)
Position:hg19 chr7:25,264,191-25,268,105Size:3,915Total Exon Count:3Strand:-
Coding Region
Position:hg19 chr7:25,264,741-25,268,058Size:3,318Coding Exon Count:3

Page Index	Sequence and Links	UniProtKB Comments	Primers	Genetic Associations	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC:2013-06-14

Sequence and Links to Tools and Databases

Genomic Sequence (chr7:25,264,191-25,268,105)			mRNA (may differ from genome)		Protein (196 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
GeneNetwork	HGNC	Lynx	MGI	neXtProt	OMIM
PubMed	Treefam	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: RFRP_HUMAN DESCRIPTION: RecName: Full=FMRFamide-related peptides; AltName: Full=Neuropeptide VF; Contains: RecName: Full=Neuropeptide NPSF; Contains: RecName: Full=Neuropeptide RFRP-1; Contains: RecName: Full=Neuropeptide RFRP-2; Contains: RecName: Full=Neuropeptide NPVF; AltName: Full=Neuropeptide RFRP-3; Flags: Precursor; FUNCTION: Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP, but RFRP-2 shows no inhibitory activity. Neuropeptide RFRP-1 induces secretion of prolactin in rats. Neuropeptide NPVF blocks morphine- induced analgesia. INTERACTION: P00519:ABL1; NbExp=1; IntAct=EBI-1753111, EBI-375543; P06241:FYN; NbExp=1; IntAct=EBI-1753111, EBI-515315; P16333:NCK1; NbExp=1; IntAct=EBI-1753111, EBI-389883; SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Isoform 1 is specifically expressed in the retina. Neuropeptides RFRP-1 and NPVF are detected in the hypothalamus. MASS SPECTROMETRY: Mass=1428.85; Method=MALDI; Range=81-92; Source=PubMed:20027225; MASS SPECTROMETRY: Mass=969.56; Method=MALDI; Range=124-131; Source=PubMed:20027225; SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.

Primer design for this transcript


	Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA. Click here to load the transcript sequence and exon structure into Primer3Plus Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence. Click here to open Exonprimer with this transcript To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Genetic Association Studies of Complex Diseases and Disorders


	Genetic Association Database (archive): NPVF CDC HuGE Published Literature: NPVF Positive Disease Associations: Body Height, Body Mass Index, Glucose, Hypertension, Insulin Resistance, Nonalcoholic Fatty Liver Disease, Pancreatic Neoplasms, Triglycerides Related Studies: Body Height , , . [PubMed 0] Body Mass Index , , . [PubMed 0] Glucose , , . [PubMed 0] &nbsp more ... click here to view the complete list

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564Benzo(a)pyrene D000643Ammonium Chloride D015283Citalopram D005839Gentamicins D008550Melatonin D013739Testosterone D014635Valproic Acid C069837fullerene C60 C028007nickel monoxide

Common Gene Haplotype Alleles


	Press "+" in the title bar above to open this section.

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 0.37 RPKM in Brain - Hypothalamus Total median expression: 0.37 RPKM View in GTEx track of Genome BrowserView at GTEx portalView GTEx Body Map

Highest median expression: 0.37 RPKM in Brain - Hypothalamus
Total median expression: 0.37 RPKM

View in GTEx track of Genome BrowserView at GTEx portalView GTEx Body Map

Microarray Expression Data


	Press "+" in the title bar above to open this section.

See Also

Human Gene USP19 (uc011bch.2)

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-3.20	47	-0.068	Picture	PostScript	Text
3' UTR	-112.94	550	-0.205	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR026297 - FMRFamide-related/fGRP

ModBase Predicted Comparative 3D Structure on Q9HCQ7


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	Genome Browser	Genome Browser	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl
	Protein Sequence	Protein Sequence
	Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Biological Process: GO:0007218 neuropeptide signaling pathway GO:0032277 negative regulation of gonadotropin secretion Cellular Component: GO:0005576 extracellular region

Descriptions from all associated GenBank mRNAs


	AF440392 - homo sapiens C7orf9 hypothetical protein mRNA, complete cds. JD291113 - Sequence 272137 from Patent EP1572962. JD127226 - Sequence 108250 from Patent EP1572962. AB040290 - homo sapiens RFRP mRNA for RFamide-related peptide precursor, complete cds. BC160068 - Synthetic construct homo sapiens clone IMAGE:100064004, MGC:193183 neuropeptide VF precursor (NPVF) mRNA, encodes complete protein. AF330057 - homo sapiens neuropeptide NPVF precursor, mRNA, complete cds. JD316020 - Sequence 297044 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A4D164, C7orf9, NM_022150, NP_071433, Q7LE27, Q96PI9, Q9HCQ7, RFRP, RFRP_HUMAN UCSC ID: uc003sxo.3 RefSeq Accession: NM_022150 Protein: Q9HCQ7 (aka RFRP_HUMAN) CCDS: CCDS5395.1

Gene Model Information

category:	coding	nonsense-mediated-decay:	no	RNA accession:	NM_022150.3
exon count:	3	CDS single in 3' UTR:	no	RNA size:	1190
ORF size:	591	CDS single in intron:	no	Alignment % ID:	99.92
txCdsPredict score:	1382.00	frame shift in genome:	no	% Coverage:	99.83
has start codon:	yes	stop codon in genome:	no	# of Alignments:	1
has end codon:	yes	retained intron:	no	# AT/AC introns	0
selenocysteine:	no	end bleed into intron:	0	# strange splices:	0

Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.